Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett

One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanth...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2012-05, Vol.17 (5), p.6071-6082
Main Authors: Hashim, Najihah Mohd, Rahmani, Mawardi, Ee, Gwendoline Cheng Lian, Sukari, Mohd Aspollah, Yahayu, Maizatulakmal, Amin, Muhamad Aizat Mohd, Ali, Abd Manaf, Go, Rusea
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Artocarpus - chemistry
Bacteria - drug effects
Biological activity
Diabetes
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Flavonoids
Free radicals
Fungi - drug effects
Infectious diseases
Inhibitory Concentration 50
Lipid peroxidation
Monophenol Monooxygenase - antagonists & inhibitors
Natural products
Phytochemicals
Plant Extracts - chemistry
Plant Extracts - pharmacology
Xanthones - chemistry
Xanthones - isolation & purification
Xanthones - pharmacology
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Summary:One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules17056071