1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

1-Deoxynojirimycin (DNJ, C₆H NO₄, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and (dayflower) as well as from several bacterial strains such as and species. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and...

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Bibliographic Details
Published in:Molecules 2016-11, Vol.21 (11), p.1600
Main Authors: Gao, Kuo, Zheng, Chenglong, Wang, Tong, Zhao, Huihui, Wang, Juan, Wang, Zhiyong, Zhai, Xing, Jia, Zijun, Chen, Jianxin, Zhou, Yingwu, Wang, Wei
Format: Article
Language:English
Subjects:
1-Deoxynojirimycin - administration & dosage
1-Deoxynojirimycin - chemistry
1-Deoxynojirimycin - isolation & purification
1-Deoxynojirimycin - pharmacology
Anti-Obesity Agents - administration & dosage
Anti-Obesity Agents - isolation & purification
Anti-Obesity Agents - pharmacology
Antiviral Agents - administration & dosage
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Bacillus - chemistry
Chromatography, High Pressure Liquid
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Molecular Structure
Morus - chemistry
Plant Leaves - chemistry
Review
Streptomyces - chemistry
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Summary:1-Deoxynojirimycin (DNJ, C₆H NO₄, 163.17 g/mol), an alkaloid azasugar or iminosugar, is a biologically active natural compound that exists in mulberry leaves and (dayflower) as well as from several bacterial strains such as and species. Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features. Therefore, the aim of this detailed review article is to summarize the existing knowledge on occurrence, extraction, purification, determination, chemistry, and bioactivities of DNJ, so that researchers may use it to explore future perspectives of research on DNJ. Moreover, possible molecular targets of DNJ will also be investigated using suitable in silico approach.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21111600