Gold Nanorods for Light-Based Lung Cancer Theranostics

Gold nanorods (AuNRs) have the potential to be used in photoacoustic (PA) imaging and plasmonic photothermal therapy (PPTT) due to their unique optical properties, biocompatibility, controlled synthesis, and tuneable surface plasmon resonances (SPRs). Conventionally, continuous-wave (CW) lasers are...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-10, Vol.19 (11), p.3318
Main Authors: Knights, Oscar B, McLaughlan, James R
Format: Article
Language:English
Subjects:
A549 Cells
Biocompatibility
Cell death
Continuous radiation
Contrast agents
Fluence
Gold
Gold - chemistry
Humans
Lasers
Light
Lung cancer
Lung Neoplasms - therapy
Metal Nanoparticles - chemistry
Mimicry
Nanoparticles
Nanotubes - chemistry
Optical properties
Photoacoustic Techniques - methods
Phototherapy - methods
Precision medicine
Surface Plasmon Resonance
Theranostic Nanomedicine
Toxicity
Tumors
Ultrasonic imaging
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Summary:Gold nanorods (AuNRs) have the potential to be used in photoacoustic (PA) imaging and plasmonic photothermal therapy (PPTT) due to their unique optical properties, biocompatibility, controlled synthesis, and tuneable surface plasmon resonances (SPRs). Conventionally, continuous-wave (CW) lasers are used in PPTT partly due to their small size and low cost. However, if pulsed-wave (PW) lasers could be used to destroy tissue then combined theranostic applications, such as PA-guided PPTT, would be possible using the same laser system and AuNRs. In this study, we present the effects of AuNR size on PA response, PW-PPTT efficacy, and PA imaging in a tissue-mimicking phantom, as a necessary step in the development of AuNRs towards clinical use. At equivalent NP/mL, the PA signal intensity scaled with AuNR size, indicating that overall mass has an effect on PA response, and reinforcing the importance of efficient tumour targeting. Under PW illumination, all AuNRs showed toxicity at a laser fluence below the maximum permissible exposure to skin, with a maximum of 80% cell-death exhibited by the smallest AuNRs, strengthening the feasibility of PW-PPTT. The theranostic potential of PW lasers combined with AuNRs has been demonstrated for application in the lung.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19113318