The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix

In this paper, we present the results of a study on the membrane-active properties of gossypol, its derivatives and their polyvinylpyrrolidone complexes as assessed by differential scanning calorimetry and by the fluorescent probe method. The latter revealed the change in polarization of the inciden...

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Bibliographic Details
Published in:Cellular & molecular biology letters 2010, Vol.15 (1), p.98-117
Main Authors: Ionov, Maksim, Tukfatullina, Ilnora, Salakhutdinov, Bakhtiyar, Baram, Nina, Bryszewska, Maria, Aripov, Takhir
Format: Article
Language:English
Subjects:
1,2-Dipalmitoylphosphatidylcholine - chemistry
Calorimetry, Differential Scanning
Differential scanning calorimetry
Dimyristoylphosphatidylcholine - chemistry
Fluorescent Dyes - chemistry
Gossypol - analogs & derivatives
Gossypol - chemistry
Gossypol - metabolism
Gossypol and its derivatives
Lipid Bilayers - chemistry
Lipid membranes
Liposomes - chemistry
Liposomes - metabolism
Membrane fluidity
Povidone - chemistry
Povidone - metabolism
Thermodynamics
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Summary:In this paper, we present the results of a study on the membrane-active properties of gossypol, its derivatives and their polyvinylpyrrolidone complexes as assessed by differential scanning calorimetry and by the fluorescent probe method. The latter revealed the change in polarization of the incident radiation caused by the action of the polyphenol on the artificial membrane lipid matrix.
ISSN:1689-1392
1425-8153
1689-1392
DOI:10.2478/s11658-009-0037-x