With great power comes great vulnerability

The clinical responses to targeted drugs are often transient and do not always translate into meaningful overall survival due to the development of resistance. We discuss here that the greater power of drug resistant cells can be associated with significant newly-acquired vulnerabilities that can be...

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Bibliographic Details
Published in:Molecular & cellular oncology 2018-11, Vol.5 (6), p.e1509488-e1509488
Main Authors: Leite de Oliveira, Rodrigo, Wang, Liqin, Bernards, Rene
Format: Article
Language:English
Subjects:
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BRAF
drug resistance
histone deacetylase inhibitor
melanoma
reactive oxygen species
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Summary:The clinical responses to targeted drugs are often transient and do not always translate into meaningful overall survival due to the development of resistance. We discuss here that the greater power of drug resistant cells can be associated with significant newly-acquired vulnerabilities that can be exploited therapeutically.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2018.1509488