Chemotherapy and molecular therapy in cervical cancer

In recent years, the treatment of locally-advanced and metastatic cervical cancer has improved greatly due to the introduction of targeted therapies, new chemotherapy combinations, and emerging treatments. Candidates for potentially curative treatment are those patients with good functional status w...

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Bibliographic Details
Published in:Reports of practical oncology and radiotherapy 2018-11, Vol.23 (6), p.533-539
Main Authors: Regalado Porras, Gabriela Olivia, Chávez Nogueda, Jessica, Poitevin Chacón, Adela
Format: Article
Language:English
Subjects:
Cervical cancer
Chemotherapy
Combination
Second primary
Special issue paper
Systemic therapy
Toxicity
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Summary:In recent years, the treatment of locally-advanced and metastatic cervical cancer has improved greatly due to the introduction of targeted therapies, new chemotherapy combinations, and emerging treatments. Candidates for potentially curative treatment are those patients with good functional status without associated comorbidities. Numerous trials have demonstrated that chemotherapy prolongs survival versus supportive care alone. In addition, polychemotherapy schemes are superior to single agent regimens. Targeted molecular agents have proven beneficial in the treatment of cervical cancer. Second-line treatment should be considered standard practice in patients with good functional status. Finally, given the poor survival outcomes in patients with metastatic disease, participation in clinical studies should always be considered the best option.
ISSN:1507-1367
2083-4640
DOI:10.1016/j.rpor.2018.09.002