Sex differences in Alzheimer’s disease and common neuropathologies of aging

Alzheimer’s dementia is significantly more common in women than in men. However, few pathological studies have addressed sex difference in Alzheimer’s disease (AD) and other brain pathologies. We leveraged postmortem data from 1453 persons who participated in one of two longitudinal community-based...

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Bibliographic Details
Published in:Acta neuropathologica 2018-12, Vol.136 (6), p.887-900
Main Authors: Oveisgharan, Shahram, Arvanitakis, Zoe, Yu, Lei, Farfel, Jose, Schneider, Julie A., Bennett, David A.
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Amyloid
Arteriosclerosis
Autopsy
Cerebral amyloid angiopathy
Dementia
Dementia disorders
DNA-binding protein
Hippocampus
Lewy bodies
Medicine
Medicine & Public Health
Neocortex
Neurosciences
Original Paper
Pathology
Risk factors
Sex differences
Tau protein
Women
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Summary:Alzheimer’s dementia is significantly more common in women than in men. However, few pathological studies have addressed sex difference in Alzheimer’s disease (AD) and other brain pathologies. We leveraged postmortem data from 1453 persons who participated in one of two longitudinal community-based studies of older adults, the Religious Orders Study and the Rush Memory and Aging Project. Postmortem examination identified AD pathologies, neocortical Lewy bodies, DNA-binding protein 43 (TDP-43), hippocampal sclerosis, gross and micro infarcts, atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. Linear and logistic regressions examined the association of sex with each of the pathologic measures. Two-thirds of subjects were women ( n  = 971; 67%), with a mean age at death of 89.8 (SD = 6.6) years in women and 87.3 (SD = 6.6) in men. Adjusted for age and education, women had higher levels on a global measure of AD pathology (estimate = 0.102, SE = 0.022, p  
ISSN:0001-6322
1432-0533
DOI:10.1007/s00401-018-1920-1