Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection

Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the anesthesiologist. Continuous delivery of oxygen and nutrients to the brain is necessary to prevent irreversible i...

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Bibliographic Details
Published in:Journal of Cerebral Blood Flow & Metabolism 2018-12, Vol.38 (12), p.2192-2208
Main Authors: Slupe, Andrew M, Kirsch, Jeffrey R
Format: Article
Language:English
Subjects:
Anesthesia - adverse effects
Anesthesia - methods
Anesthetics - pharmacology
Animals
Brain - drug effects
Brain - metabolism
Cerebrovascular Circulation - drug effects
Cerebrovascular Circulation - physiology
Humans
Neuroprotection - drug effects
Review
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Summary:Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the anesthesiologist. Continuous delivery of oxygen and nutrients to the brain is necessary to prevent irreversible injury and arises from a complex series of regulatory mechanisms that ensure uninterrupted cerebral blood flow. Our understanding of these regulatory mechanisms and the effects of anesthetics on them has been driven by the tireless work of pioneers in the field. It is of paramount importance that the anesthesiologist shares this understanding. Herein, we will review the physiological determinants of cerebral blood flow and how delivery of anesthesia impacts these processes.
ISSN:0271-678X
1559-7016
1559-7016
DOI:10.1177/0271678X18789273