Gut Microbiota Disruption in Septic Shock Patients: A Pilot Study

BACKGROUND The composition of the intestinal microbiota and its effect on septic shock patients in the intensive care unit (ICU) is unknown. In the present study we explored the hypothesis that bacterial diversity is decreased in septic shock patients and that this diversity may be improved by use o...

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Bibliographic Details
Published in:Medical science monitor 2018-11, Vol.24, p.8639-8646
Main Authors: Wan, You-Dong, Zhu, Rui-Xue, Wu, Zi-Qian, Lyu, Shao-Yan, Zhao, Lian-Xing, Du, Zhong-Jun, Pan, Xin-Ting
Format: Article
Language:English
Subjects:
Clinical Research
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Summary:BACKGROUND The composition of the intestinal microbiota and its effect on septic shock patients in the intensive care unit (ICU) is unknown. In the present study we explored the hypothesis that bacterial diversity is decreased in septic shock patients and that this diversity may be improved by use of probiotics or enteral nutrition. MATERIAL AND METHODS A total of 15 stool samples were collected prospectively from septic shock patients in the ICU, while 15 samples from healthy subjects served as controls. Bacterial DNA was submitted for 16S rDNA gene sequencing. The relationship between intestinal microbiota and prognosis was evaluated. RESULTS Significantly lower bacterial diversity was found in septic shock patients compared with healthy subjects (p
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.911768