Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression

• Published in: Oncotarget 2018-11, Vol.9 (92), p.36457-36473
• Main Authors: Simonneau, Marie, Frouin, Eric, Huguier, Vincent, Jermidi, Cynthia, Jégou, Jean François, Godet, Julie, Barra, Anne, Paris, Isabelle, Levillain, Pierre, Cordier-Dirikoc, Sevda, Pedretti, Nathalie, Bernard, François Xavier, Lecron, Jean Claude, Morel, Franck, Favot, Laure
• Format: Article
• Language: English
• Subjects: Cancer; Life Sciences; Research Paper
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.26355

Cutaneous squamous cell carcinoma (cSCC) is the second most common keratinocyte malignancy and accounts for 20% of skin cancer deaths. Cancer is closely related to inflammation, but the contribution of the tumor microenvironment to cSCC development is poorly understood. We previously showed that oncostatin M (OSM), a cytokine belonging to the IL-6 family, promotes normal keratinocyte proliferation and migration, skin inflammation, and epidermal hyperplasia, both and . Here, we show that OSM is overexpressed in human cSCC and is associated with type 1 immune polarization. , OSM induced STAT-3 and ERK signaling, modified the expression of genes involved in cytokine signaling, proliferation, inhibition of apoptosis, and immune responses, and promoted proliferation and migration of malignant keratinocyte PDVC57 cells. PDVC57 cells grafted in the skin of mice led to rapid cSCC development, associated with OSM expression by tumor-infiltrating neutrophils. Finally, the absence of OSM (OSM-KO mice) led to a 30% reduction of tumor size and reduced M2 polarization in the tumor microenvironment. Globally, these results support a pro-tumoral role of OSM in cSCC development and suggest that a new therapeutic approach targeting this cytokine could be considered.