Volatilomic insight of head and neck cancer via the effects observed on saliva metabolites

Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. We applied h...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2018-12, Vol.8 (1), p.17725-10, Article 17725
Main Authors: Taware, Ravindra, Taunk, Khushman, Pereira, Jorge A. M., Shirolkar, Amey, Soneji, Dharmesh, Câmara, José S., Nagarajaram, H. A., Rapole, Srikanth
Format: Article
Language:English
Subjects:
631/61/320
631/67/1665/3016
639/638/11/296
692/53/2421
82/58
Adaptation
Adult
Aged
Aged, 80 and over
Cancer
Case-Control Studies
Dichlorobenzene
Female
Gas chromatography
Gas Chromatography-Mass Spectrometry - methods
Head & neck cancer
Head and Neck Neoplasms - metabolism
Headspace
Humanities and Social Sciences
Humans
Male
Mass spectrometry
Mass spectroscopy
Metabolic Networks and Pathways - physiology
Metabolic pathways
Metabolism
Metabolites
Middle Aged
multidisciplinary
ROC Curve
Saliva
Saliva - metabolism
Science
Science (multidisciplinary)
Solid phase methods
Solid Phase Microextraction - methods
Volatile Organic Compounds - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. We applied headspace solid phase microextraction coupled with gas chromatography-mass spectrometry analysis of saliva samples collected from 59 human subjects (HNC − 32, Control − 27). We identified and quantified 48 volatile organic metabolites (VOMs) and observed profound effects of HNC on these metabolites. These effects were VOM specific and significantly differed in the biologically comparable healthy controls. HNC induced changes in salivary VOM composition were well attributed to in vivo metabolic effects. A panel of 15 VOMs with variable importance in projection (VIP) score >1, false discovery rate (FDR) corrected p -value 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-35854-x