Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats

• Published in: BioMed research international 2018-01, Vol.2018 (2018), p.1-9
• Main Authors: Kuiate, Jules-Roger, Arrey Tarkang, Protus, Nolé, Tsabang, Tchokouaha Yamthe, Lauve Rachel, Tchamgoue, Armelle D., Agbor, Gabriel Agbor
• Format: Article
• Language: English
• Subjects: Alanine; Alanine transaminase; Alanine Transaminase - metabolism; Albinism; Alkaline phosphatase; Animals; Antioxidants; Antioxidants - metabolism; Aspartate; Aspartate aminotransferase; Aspartate Aminotransferases - metabolism; Biomedical research; Catalase; Catalase - metabolism; Congestion; Costus - chemistry; Costus afer; Creatinine; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - metabolism; Enzymes; Gene expression; Glutathione; Glutathione - metabolism; Heart; Heart - drug effects; Herbal medicine; Infiltration; Insulin resistance; Intubation; Kidney - drug effects; Kidney - metabolism; Kidneys; L-Lactate dehydrogenase; Lactate dehydrogenase; Lactic acid; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Liver; Liver - drug effects; Liver - metabolism; Male; Medicinal plants; Medicine, Botanic; Medicine, Herbal; Metabolism; Modulators; Oxidative stress; Oxidative Stress - drug effects; Parameters; Peroxidation; Phosphatases; Plant Extracts - pharmacology; Plant tissues; Protective Agents - pharmacology; Proteins; Rats; Rats, Wistar; Rodents; Seeds; Streptozocin; Streptozocin - pharmacology; Superoxide; Superoxide dismutase; Superoxide Dismutase - metabolism; Toxicity; Urea; Ureas
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2018/4907648

Medicinal plants are efficient modulators of oxidative stress associated with diabetes mellitus. This study evaluated the cardio-, reno-, and hepato-antioxidant status of hydroethanolic extract of Costus afer on streptozotocin-intoxicated diabetic rats. Experimental animals were daily administered with hydroethanolic extract of C. afer by oral intubation for eight weeks (60 days), after which the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and lipid peroxidation marker (MDA) were evaluated in the heart, liver, and kidney homogenates. Plasma biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, creatinine, and urea were determined. Meanwhile, parts of the heart, kidneys, and liver were histopathologically examined. Streptozotocin administration induced toxicity in the cardiac, hepatic, and renal tissues by stimulating significant increases (p