When less is more: Thinner fronto-parietal cortices are associated with better forward digit span performance during early childhood

• Published in: Neuropsychologia 2018-12, Vol.121, p.11-18
• Main Authors: Botdorf, Morgan, Riggins, Tracy
• Format: Article
• Language: English
• Subjects: Cortical thickness; Early childhood; Structural MRI; Working memory
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2018.10.020

Although research shows that working memory improves during early childhood, it remains unclear how the fronto-parietal network of cortical regions, known to support this ability in adults, relates to changes in young children. Measures of cortical thickness may be useful in investigating this association as they reflect age-related differences in gray matter and have been proposed to support age-related improvements in other cognitive abilities, but have only sparingly been tested empirically in early childhood. The present study sought to investigate relations between cortical thickness and performance on a digit span task in 200 4- to 8-year-old children using both a priori defined regions of interest related to working memory (superior frontal cortex, middle frontal cortex, anterior cingulate cortex, superior parietal cortex) and whole brain analyses. Results indicated a significant association between cortical thickness in each a priori defined fronto-parietal region and performance on digit span, such that those with a thinner cortex recalled more items than those with a thicker cortex. Similar regions emerged from the whole brain analyses, as did several other regions not typically included in the fronto-parietal network. Results of a mediation analysis indicated that age-related differences in behavior were partially explained by variations in thickness of anterior cingulate cortex, suggesting a potentially important role for this structure during early childhood. Overall, these results suggest that in children as young as 4 years of age there are associations between working memory abilities and thickness in cortical areas known to support working memory in adults. •Relations between age, digit span, and cortical thickness in children were assessed.•Associations were assessed using both a priori regions and whole brain analyses.•Cortical thickness in fronto-parietal regions related to digit span score.•Anterior cingulate cortex mediated the association between age and digit span.•Development of fronto-parietal regions relates to working memory in young children.