Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis

Limited evidence has suggested that circulating levels of the omega-9 fatty acid, oleic acid, may be related to greater risks of adverse cardiovascular outcomes. We aimed to determine whether plasma oleic acid may be independently associated with clinical and subclinical cardiovascular disease (CVD)...

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Published in:Journal of clinical lipidology 2018-11, Vol.12 (6), p.1404-1412
Main Authors: Steffen, Brian T., Duprez, Daniel, Szklo, Moyses, Guan, Weihua, Tsai, Michael Y.
Format: Article
Language:English
Subjects:
All-cause death
Atherosclerosis - blood
Atherosclerosis - epidemiology
Atherosclerosis - ethnology
Atherosclerosis - mortality
Cardiovascular disease
Ethnicity - statistics & numerical data
Fatty acids
Female
Heart failure
Humans
Male
Middle Aged
Oleic Acid - blood
Risk Factors
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Summary:Limited evidence has suggested that circulating levels of the omega-9 fatty acid, oleic acid, may be related to greater risks of adverse cardiovascular outcomes. We aimed to determine whether plasma oleic acid may be independently associated with clinical and subclinical cardiovascular disease (CVD) and all-cause mortality in a large multiethnic cohort. Plasma fatty acids were measured by gas chromatography–flame ionization in 6568 participants of the Multi-Ethnic Study of Atherosclerosis. The presence of coronary artery calcium (CAC) and aortic valve calcification (AVC) was determined by computed tomography, and carotid plaque was assessed by ultrasound. Incident CVD was defined as myocardial infarction, fatal coronary heart disease, resuscitated cardiac arrest, stroke, or stroke death. Heart failure (HF) was adjudicated from clinical records. Relative risk regression estimated plasma oleic acid-related rate ratios for prevalent CAC, AVC, and carotid plaque. Cox regression estimated hazard ratios (HRs) for CVD, HF, and all-cause mortality over a median 13-year follow-up. Individuals in top quartiles of oleic acid showed greater rate ratios of CAC, AVC, and carotid plaque (all P 
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2018.08.004