Strategies for Improving Ocular Drug Bioavailability and Corneal Wound Healing with Chitosan-Based Delivery Systems

The main inconvenience of conventional eye drops is the rapid washout of the drugs due to nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be improved by either prolonging retention time in the cul-de-sac or by increasing the ocular permeability. The focus of this re...

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Bibliographic Details
Published in:Polymers 2018-11, Vol.10 (11), p.1221
Main Authors: Irimia, Teodora, Ghica, Mihaela Violeta, Popa, Lăcrămioara, Anuţa, Valentina, Arsene, Andreea-Letiţia, Dinu-Pîrvu, Cristina-Elena
Format: Article
Language:English
Subjects:
Bioavailability
Biocompatibility
Cellulose
Chitosan
Cornea
Drug delivery systems
Endothelium
Epithelium
Gels
Hydrogels
Kinases
Ophthalmology
Patient compliance
Permeability
Pharmaceutical industry
Polymers
Retention
Review
Tissue engineering
Viscosity
Wound healing
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Summary:The main inconvenience of conventional eye drops is the rapid washout of the drugs due to nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be improved by either prolonging retention time in the cul-de-sac or by increasing the ocular permeability. The focus of this review is to highlight some chitosan-based drug delivery approaches that proved to have good clinical efficacy and high potential for use in ophthalmology. They are exemplified by recent studies exploring in-depth the techniques and mechanisms in order to improve ocular bioavailability of the active substances. Used alone or in combination with other compounds with synergistic action, chitosan enables ocular retention time and corneal permeability. Associated with other stimuli-responsive polymers, it enhances the mechanical strength of the gels. Chitosan and its derivatives increase drug permeability through the cornea by temporarily opening tight junctions between epithelial cells. Different types of chitosan-based colloidal systems have the potential to overcome the ocular barriers without disturbing the vision process. Chitosan also plays a key role in improving corneal wound healing by stimulating the migration of keratinocytes when it is used alone or in combination with other compounds with synergistic action.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym10111221