Hypoxia-inducible factor-1α regulation of myeloid cells

Hematopoietic myeloblasts give rise to macrophages, dendritic cells, and neutrophils. Circulating myeloid cells detect invading microbes using pattern recognition receptors and subsequently orchestrate an innate immune response to contain and kill the pathogens. This innate immune response establish...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2018-12, Vol.96 (12), p.1293-1306
Main Authors: Stothers, C. L., Luan, L., Fensterheim, B. A., Bohannon, J. K.
Format: Article
Language:English
Subjects:
Arteriosclerosis
Biomedical and Life Sciences
Biomedicine
Dendritic cells
Human Genetics
Hypoxia
Hypoxia-inducible factors
Immune response
Immunogenicity
Infections
Inflammation
Innate immunity
Internal Medicine
Leukocytes (neutrophilic)
Macrophages
Molecular Medicine
Myeloid cells
Pathogens
Pattern recognition receptors
Review
Transcription factors
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Summary:Hematopoietic myeloblasts give rise to macrophages, dendritic cells, and neutrophils. Circulating myeloid cells detect invading microbes using pattern recognition receptors and subsequently orchestrate an innate immune response to contain and kill the pathogens. This innate immune response establishes an inflammatory niche characterized by hypoxia due to host and pathogen factors. Hypoxia-inducible factor (HIF) transcription factors are the primary regulators of the myeloid response to hypoxia. In particular, HIF-1α is a critical hub that integrates hypoxic and immunogenic signals during infection or inflammation. Hypoxia induces HIF-1α stabilization, which drives metabolic and phenotypic reprogramming of myeloid cells to maximize antimicrobial potential. HIF-1α activity in myeloid-derived cells enhances the host response to infection, but may also play a role in pathogenic inflammatory processes, such as atherosclerosis. In this review, we summarize recent advances that have elucidated the mechanism by which myeloid cells regulate HIF-1α activity and, in turn, how HIF-1α shapes myeloid cell function.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-018-1710-1