Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus

Highlights • Subunit composition of glutamate and GABA receptors changes in status epilepticus. • AMPA receptors: elevated GluA1/GluA2 ratio. • NMDA receptors: elevated GluN2B/GluN2A ratio. • GABA receptors: elevated α2/α1 ratio. • These changes promote hyperexcitability and self-sustaining seizures...

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Bibliographic Details
Published in:Epilepsy research 2014-05, Vol.108 (4), p.605-615
Main Authors: Loddenkemper, Tobias, Talos, Delia M, Cleary, Ryan T, Joseph, Annelise, Sánchez Fernández, Iván, Alexopoulos, Andreas, Kotagal, Prakash, Najm, Imad, Jensen, Frances E
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Cerebral Cortex - metabolism
Child
Child, Preschool
Children
Epilepsy
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Infant
Infant, Newborn
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Protein Subunits - metabolism
Receptor subunit composition
Receptors, GABA - metabolism
Receptors, Glutamate - metabolism
Refractory status epilepticus
Status Epilepticus - metabolism
Therapy
Young Adult
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Summary:Highlights • Subunit composition of glutamate and GABA receptors changes in status epilepticus. • AMPA receptors: elevated GluA1/GluA2 ratio. • NMDA receptors: elevated GluN2B/GluN2A ratio. • GABA receptors: elevated α2/α1 ratio. • These changes promote hyperexcitability and self-sustaining seizures.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2014.01.015