Comprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households

Background Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs). To develop interventions to prevent recurrent infections, household attributes and individual practices influencing S. aureus colonization must be discerned. Methods Households of healthy children with...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric research 2018-11, Vol.84 (5), p.668-676
Main Authors: Mork, Ryan L., Hogan, Patrick G., Muenks, Carol E., Boyle, Mary G., Thompson, Ryley M., Morelli, John J., Sullivan, Melanie L., Gehlert, Sarah J., Ross, David G., Yn, Alicia, Bubeck Wardenburg, Juliane, Rzhetsky, Andrey, Burnham, Carey-Ann D., Fritz, Stephanie A.
Format: Article
Language:English
Subjects:
Adult
Carrier State
Child
Child, Preschool
Clinical Research Article
Cohort Studies
Family Characteristics
Female
Households
Humans
Hygiene
Male
Medicine
Medicine & Public Health
Methicillin-Resistant Staphylococcus aureus - classification
Methicillin-Resistant Staphylococcus aureus - growth & development
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Models, Theoretical
Pathogens
Pediatric Surgery
Pediatrics
Seasons
Species Specificity
Staphylococcus infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs). To develop interventions to prevent recurrent infections, household attributes and individual practices influencing S. aureus colonization must be discerned. Methods Households of healthy children with methicillin-resistant S. aureus (MRSA) SSTI ( n  = 150; 671 participants) were interviewed regarding health history, activities, and hygiene practices. S. aureus colonization was assessed in household members, and recovered isolates were typed by repetitive sequence-based PCR. Results The number of unique strain types in a household (median 1, range 0–7) correlated with the number of colonized individuals ( p  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-018-0113-x