Standardization of the HbA2 Assay

BACKGROUNDA project for the standardization of HbA2 was launched by the IFCC back in 2004. MATERIALS AND METHODSIn this work we report on the state-of-the-art of the project on standardization of HbA2. Data obtained from various EQAS studies, and from previous experimental evaluations, are presented...

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Bibliographic Details
Published in:EJIFCC 2018-12, Vol.29 (4), p.298-302
Main Authors: Paleari, Renata, Mosca, Andrea
Format: Article
Language:English
Subjects:
Review
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Summary:BACKGROUNDA project for the standardization of HbA2 was launched by the IFCC back in 2004. MATERIALS AND METHODSIn this work we report on the state-of-the-art of the project on standardization of HbA2. Data obtained from various EQAS studies, and from previous experimental evaluations, are presented. RESULTSWe have proven that biases between various commercial methods are still currently significant. We have also shown that calibration by commutable control materials may halve the inter-method variability. CONCLUSIONSThe foundation of the reference system for HbA2, together with a brief preliminary presentation of the proposed primary reference measurement procedure based on ID-MS are outlined.
ISSN:1650-3414
1650-3414