Evaluation of a Summary Score for Dyslipidemia, Oxidative Stress and Inflammation (The Doi Score) in Women with Polycystic Ovary Syndrome and its Relationship with Obesity

Polycystic ovary syndrome (PCOS) is a cardiometabolic disorder whose features include dyslipidemia, increased oxidative stress (OS, oxy) and chronic inflammation. The aim of this study was to investigate the ability of a summary score for dyslipidemia, OS and inflammation (the DOI score) to discrimi...

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Bibliographic Details
Published in:Journal of medical biochemistry 2018-12, Vol.37 (4), p.476-485
Main Authors: Blagojević, Iva Perović, Ignjatović, Svetlana, Macut, Djuro, Kotur-Stevuljević, Jelena, Božić-Antić, Ivana, Vekić, Jelena, Bjekić-Macut, Jelica, Kastratović-Kotlica, Biljana, Andrić, Zoran, Ilić, Dušan
Format: Article
Language:English
Subjects:
Antioxidants
Diagnostic systems
DOI score
Dyslipidemia
Inflammation
Malondialdehyde
Metabolic disorders
Obesity
Original Paper
Oxidation
Oxidative stress
Parameters
Paraoxonase
Paraoxonase 1
Patients
Polycystic ovary syndrome
Proteins
Weight
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Summary:Polycystic ovary syndrome (PCOS) is a cardiometabolic disorder whose features include dyslipidemia, increased oxidative stress (OS, oxy) and chronic inflammation. The aim of this study was to investigate the ability of a summary score for dyslipidemia, OS and inflammation (the DOI score) to discriminate PCOS patients from healthy individuals and to evaluate the effect of obesity on individual scores and the DOI score in patients. Lipid status parameters, OS status parameters (advanced oxidation protein products; total oxidative status; prooxidant-antioxidant balance; malondialdehyde; total protein sulphydryl groups and paraoxonase 1 activity) and CRP were measured in 114 patients and 50 controls using standardised assays. The DOI score was calculated as the sum of dyslipidemia, oxy and inflammation scores, determined as Z-score values for every subject in relation to the controls. PCOS patients had significantly higher oxy-score compared to controls (P
ISSN:1452-8258
1452-8266
1452-8266
DOI:10.2478/jomb-2018-0008