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Flush with a flash: natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00414e
Controlled O 2 ˙ – production promotes the decomposition of S -nitrosothiols, forming highly aggressive ONOO – . S -Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O 2 ˙ – promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO –...
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Published in: | MedChemComm 2018-10, Vol.9 (12), p.1994-1999 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Controlled O
2
˙
–
production promotes the decomposition of
S
-nitrosothiols, forming highly aggressive ONOO
–
.
S
-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O
2
˙
–
promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO
–
). Since the production of O
2
˙
–
can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine. |
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ISSN: | 2040-2503 2040-2511 |
DOI: | 10.1039/c8md00414e |