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Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth
Preterm birth is defined as delivery before 37 completed weeks of pregnancy, and it is the leading cause of neonatal morbidity and mortality. Oxidative stress is recognized as an important factor in the pathogenesis of premature labor. We conducted this analysis to investigate the safety of administ...
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Published in: | Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-8 |
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creator | Banach, Maciej Horzelski, Wojciech Oszukowski, Przemysław Suliburska, Joanna Kocyłowski, Rafał Gaj, Zuzanna Grzesiak, Mariusz von Kaisenberg, C. |
description | Preterm birth is defined as delivery before 37 completed weeks of pregnancy, and it is the leading cause of neonatal morbidity and mortality. Oxidative stress is recognized as an important factor in the pathogenesis of premature labor. We conducted this analysis to investigate the safety of administration of the tocolytic drug Atosiban—a reversible, competitive antagonist of the oxytocin receptor in the treatment of preterm birth and its impact on the level of oxidative stress in pregnant women after 48 hours of tocolytic treatment. This prospective study was conducted between March 2016 and August 2017 at the Obstetric Clinic of the Polish Mother’s Memorial Hospital Research Institute. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values as well as 3-nitrotyrosine, carbonyl, and thiol group levels were measured using an ELISA test in serum and plasma of 56 pregnant women before and after 48 hours of continuous administration of Atosiban. We found that TAS levels decreased almost twice after the 48-hour drug administration (0.936 ± 0.360 mmol/L vs. 0.582 ± 0.305 mmol/L, P |
doi_str_mv | 10.1155/2018/3919106 |
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Oxidative stress is recognized as an important factor in the pathogenesis of premature labor. We conducted this analysis to investigate the safety of administration of the tocolytic drug Atosiban—a reversible, competitive antagonist of the oxytocin receptor in the treatment of preterm birth and its impact on the level of oxidative stress in pregnant women after 48 hours of tocolytic treatment. This prospective study was conducted between March 2016 and August 2017 at the Obstetric Clinic of the Polish Mother’s Memorial Hospital Research Institute. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values as well as 3-nitrotyrosine, carbonyl, and thiol group levels were measured using an ELISA test in serum and plasma of 56 pregnant women before and after 48 hours of continuous administration of Atosiban. We found that TAS levels decreased almost twice after the 48-hour drug administration (0.936 ± 0.360 mmol/L vs. 0.582 ± 0.305 mmol/L, P<0.001) while TOS increased from 18.217 ± 16.093 μmol/L to 30.442 ± 30.578 μmol/L (P<0.001). We also found a significant increase in OSI index—almost a threefold increase from 0.022 ± 0.022 to 0.075 ± 0.085, P<0.001. In addition, statistically significant differences in the level of carbonyl groups were found. It increased from 65.358 ± 31.332 μmol/L to 97.982 ± 38.047 μmol/L (P<0.001), which indicates increased oxidation of plasma proteins. Furthermore, patients who gave birth prematurely had higher levels of TOS after a 48-hour drug administration than the second group with labor after 37 weeks of pregnancy (42.803 ± 34.683 μmol/L vs. 25.792 ± 27.821 μmol/L, P<0.031). The obtained results clearly indicate that pregnant women during tocolytic treatment with Atosiban are in a state of increased oxidative stress and occurrence of preterm birth can be associated with this phenomenon. This trial is registered with NCT03570294.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2018/3919106</identifier><identifier>PMID: 30622667</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Antioxidants ; Biomarkers ; Blood proteins ; Clinical Study ; Drug dosages ; Endocrinology ; Enzyme-linked immunosorbent assay ; Ethylenediaminetetraacetic acid ; Gynecology ; Hospitals ; Infants (Premature) ; Mortality ; Obstetrics ; Oxidative stress ; Poland ; Pregnancy ; Pregnancy complications ; Pregnant women ; Premature birth ; Proteins ; Womens health</subject><ispartof>Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-8</ispartof><rights>Copyright © 2018 Mariusz Grzesiak et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Mariusz Grzesiak et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Mariusz Grzesiak et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-337e1fb1c45607fc5bf4335d76ba3edd4ecf89a5d5ceac1d7e4bf619ee717663</citedby><cites>FETCH-LOGICAL-c499t-337e1fb1c45607fc5bf4335d76ba3edd4ecf89a5d5ceac1d7e4bf619ee717663</cites><orcidid>0000-0001-6690-6874 ; 0000-0003-0306-0239 ; 0000-0001-5554-1937 ; 0000-0002-1803-1935 ; 0000-0002-6900-4347 ; 0000-0002-0937-8427 ; 0000-0002-3690-5368 ; 0000-0003-4094-7103</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2158188990/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2158188990?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30622667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Giustarini, Daniela</contributor><contributor>Daniela Giustarini</contributor><creatorcontrib>Banach, Maciej</creatorcontrib><creatorcontrib>Horzelski, Wojciech</creatorcontrib><creatorcontrib>Oszukowski, Przemysław</creatorcontrib><creatorcontrib>Suliburska, Joanna</creatorcontrib><creatorcontrib>Kocyłowski, Rafał</creatorcontrib><creatorcontrib>Gaj, Zuzanna</creatorcontrib><creatorcontrib>Grzesiak, Mariusz</creatorcontrib><creatorcontrib>von Kaisenberg, C.</creatorcontrib><title>Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Preterm birth is defined as delivery before 37 completed weeks of pregnancy, and it is the leading cause of neonatal morbidity and mortality. Oxidative stress is recognized as an important factor in the pathogenesis of premature labor. We conducted this analysis to investigate the safety of administration of the tocolytic drug Atosiban—a reversible, competitive antagonist of the oxytocin receptor in the treatment of preterm birth and its impact on the level of oxidative stress in pregnant women after 48 hours of tocolytic treatment. This prospective study was conducted between March 2016 and August 2017 at the Obstetric Clinic of the Polish Mother’s Memorial Hospital Research Institute. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values as well as 3-nitrotyrosine, carbonyl, and thiol group levels were measured using an ELISA test in serum and plasma of 56 pregnant women before and after 48 hours of continuous administration of Atosiban. We found that TAS levels decreased almost twice after the 48-hour drug administration (0.936 ± 0.360 mmol/L vs. 0.582 ± 0.305 mmol/L, P<0.001) while TOS increased from 18.217 ± 16.093 μmol/L to 30.442 ± 30.578 μmol/L (P<0.001). We also found a significant increase in OSI index—almost a threefold increase from 0.022 ± 0.022 to 0.075 ± 0.085, P<0.001. In addition, statistically significant differences in the level of carbonyl groups were found. It increased from 65.358 ± 31.332 μmol/L to 97.982 ± 38.047 μmol/L (P<0.001), which indicates increased oxidation of plasma proteins. Furthermore, patients who gave birth prematurely had higher levels of TOS after a 48-hour drug administration than the second group with labor after 37 weeks of pregnancy (42.803 ± 34.683 μmol/L vs. 25.792 ± 27.821 μmol/L, P<0.031). The obtained results clearly indicate that pregnant women during tocolytic treatment with Atosiban are in a state of increased oxidative stress and occurrence of preterm birth can be associated with this phenomenon. This trial is registered with NCT03570294.</description><subject>Analysis</subject><subject>Antioxidants</subject><subject>Biomarkers</subject><subject>Blood proteins</subject><subject>Clinical Study</subject><subject>Drug dosages</subject><subject>Endocrinology</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Gynecology</subject><subject>Hospitals</subject><subject>Infants (Premature)</subject><subject>Mortality</subject><subject>Obstetrics</subject><subject>Oxidative stress</subject><subject>Poland</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnant women</subject><subject>Premature birth</subject><subject>Proteins</subject><subject>Womens health</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqN0c1rFDEYBvBBFPuhN88S8CLo2nxMMpOLsBY_ioUKLngMmeTNbspMsibZ1v73Zt11q548JZAfT96Xp2meEfyGEM7PKCb9GZNEEiweNMdEtnSGpWwfHu4YHzUnOV9jLBhtyePmiGFBqRDdcfP56oe3uvgbQF9LgpyRD-hbnCCgRQJdwKJbX1ZoXmL2gw7IxYQupjUE68MSfUlQIE3onU9l9aR55PSY4en-PG0WH94vzj_NLq8-XpzPL2emlbLMGOuAuIGYlgvcOcMH1zLGbScGzcDaFozrpeaWG9CG2A7awQkiATrSCcFOm7e72PVmmMAaCCXpUa2Tn3S6U1F79fdL8Cu1jDdKMNz2vwJe7gNS_L6BXNTks4Fx1AHiJitKBBeCY95X-uIfeh03KdTtquI96Xsp8b1a6hGUDy7Wf802VM0FpnVsQruqXu-USTHnBO4wMsFqW6XaVqn2VVb-_M81D_h3dxW82oGVD1bf-v-Mg2rA6XtNCWFUsJ8Tfa91</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Banach, Maciej</creator><creator>Horzelski, Wojciech</creator><creator>Oszukowski, Przemysław</creator><creator>Suliburska, Joanna</creator><creator>Kocyłowski, Rafał</creator><creator>Gaj, Zuzanna</creator><creator>Grzesiak, Mariusz</creator><creator>von Kaisenberg, C.</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6690-6874</orcidid><orcidid>https://orcid.org/0000-0003-0306-0239</orcidid><orcidid>https://orcid.org/0000-0001-5554-1937</orcidid><orcidid>https://orcid.org/0000-0002-1803-1935</orcidid><orcidid>https://orcid.org/0000-0002-6900-4347</orcidid><orcidid>https://orcid.org/0000-0002-0937-8427</orcidid><orcidid>https://orcid.org/0000-0002-3690-5368</orcidid><orcidid>https://orcid.org/0000-0003-4094-7103</orcidid></search><sort><creationdate>20180101</creationdate><title>Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth</title><author>Banach, Maciej ; Horzelski, Wojciech ; Oszukowski, Przemysław ; Suliburska, Joanna ; Kocyłowski, Rafał ; Gaj, Zuzanna ; Grzesiak, Mariusz ; von Kaisenberg, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-337e1fb1c45607fc5bf4335d76ba3edd4ecf89a5d5ceac1d7e4bf619ee717663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Antioxidants</topic><topic>Biomarkers</topic><topic>Blood proteins</topic><topic>Clinical Study</topic><topic>Drug dosages</topic><topic>Endocrinology</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Gynecology</topic><topic>Hospitals</topic><topic>Infants (Premature)</topic><topic>Mortality</topic><topic>Obstetrics</topic><topic>Oxidative stress</topic><topic>Poland</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnant women</topic><topic>Premature birth</topic><topic>Proteins</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banach, Maciej</creatorcontrib><creatorcontrib>Horzelski, Wojciech</creatorcontrib><creatorcontrib>Oszukowski, Przemysław</creatorcontrib><creatorcontrib>Suliburska, Joanna</creatorcontrib><creatorcontrib>Kocyłowski, Rafał</creatorcontrib><creatorcontrib>Gaj, Zuzanna</creatorcontrib><creatorcontrib>Grzesiak, Mariusz</creatorcontrib><creatorcontrib>von Kaisenberg, C.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banach, Maciej</au><au>Horzelski, Wojciech</au><au>Oszukowski, Przemysław</au><au>Suliburska, Joanna</au><au>Kocyłowski, Rafał</au><au>Gaj, Zuzanna</au><au>Grzesiak, Mariusz</au><au>von Kaisenberg, C.</au><au>Giustarini, Daniela</au><au>Daniela Giustarini</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Preterm birth is defined as delivery before 37 completed weeks of pregnancy, and it is the leading cause of neonatal morbidity and mortality. Oxidative stress is recognized as an important factor in the pathogenesis of premature labor. We conducted this analysis to investigate the safety of administration of the tocolytic drug Atosiban—a reversible, competitive antagonist of the oxytocin receptor in the treatment of preterm birth and its impact on the level of oxidative stress in pregnant women after 48 hours of tocolytic treatment. This prospective study was conducted between March 2016 and August 2017 at the Obstetric Clinic of the Polish Mother’s Memorial Hospital Research Institute. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values as well as 3-nitrotyrosine, carbonyl, and thiol group levels were measured using an ELISA test in serum and plasma of 56 pregnant women before and after 48 hours of continuous administration of Atosiban. We found that TAS levels decreased almost twice after the 48-hour drug administration (0.936 ± 0.360 mmol/L vs. 0.582 ± 0.305 mmol/L, P<0.001) while TOS increased from 18.217 ± 16.093 μmol/L to 30.442 ± 30.578 μmol/L (P<0.001). We also found a significant increase in OSI index—almost a threefold increase from 0.022 ± 0.022 to 0.075 ± 0.085, P<0.001. In addition, statistically significant differences in the level of carbonyl groups were found. It increased from 65.358 ± 31.332 μmol/L to 97.982 ± 38.047 μmol/L (P<0.001), which indicates increased oxidation of plasma proteins. Furthermore, patients who gave birth prematurely had higher levels of TOS after a 48-hour drug administration than the second group with labor after 37 weeks of pregnancy (42.803 ± 34.683 μmol/L vs. 25.792 ± 27.821 μmol/L, P<0.031). The obtained results clearly indicate that pregnant women during tocolytic treatment with Atosiban are in a state of increased oxidative stress and occurrence of preterm birth can be associated with this phenomenon. This trial is registered with NCT03570294.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30622667</pmid><doi>10.1155/2018/3919106</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6690-6874</orcidid><orcidid>https://orcid.org/0000-0003-0306-0239</orcidid><orcidid>https://orcid.org/0000-0001-5554-1937</orcidid><orcidid>https://orcid.org/0000-0002-1803-1935</orcidid><orcidid>https://orcid.org/0000-0002-6900-4347</orcidid><orcidid>https://orcid.org/0000-0002-0937-8427</orcidid><orcidid>https://orcid.org/0000-0002-3690-5368</orcidid><orcidid>https://orcid.org/0000-0003-4094-7103</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Analysis Antioxidants Biomarkers Blood proteins Clinical Study Drug dosages Endocrinology Enzyme-linked immunosorbent assay Ethylenediaminetetraacetic acid Gynecology Hospitals Infants (Premature) Mortality Obstetrics Oxidative stress Poland Pregnancy Pregnancy complications Pregnant women Premature birth Proteins Womens health |
title | Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth |
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