Lung Cancer with a Small Cell Carcinoma Component Diagnosed from Pleural Effusion and a Squamous Cell Carcinoma Component Diagnosed from the Tumor

There have been few reports on the accuracy of the diagnosis of small-cell carcinoma based on a cytological examination of malignant pleural effusion, so whether or not such a diagnosis is possible using this approach alone remains unclear. We herein report a 76-year-old Japanese man in whom small-c...

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Bibliographic Details
Published in:Internal Medicine 2018/12/01, Vol.57(23), pp.3419-3422
Main Authors: Zaizen, Yoshiaki, Tokito, Takaaki, Masuda, Ken, Azuma, Koichi, Naito, Yoshiki, Tsuneyoshi, Shingo, Sakazaki, Yuki, Matsuo, Norikazu, Ishii, Hidenobu, Yamada, Kazuhiko, Akiba, Jun, Hoshino, Tomoaki
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biopsy
Biopsy, Needle
Carboplatin
Carboplatin - therapeutic use
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Case Report
cytology
Cytopathology
Diagnosis
Docetaxel - therapeutic use
Etoposide
Etoposide - therapeutic use
Humans
Immunohistochemistry
Internal medicine
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Male
malignant pleural effusion
non-small cell lung cancer
Pleural effusion
Pleural Effusion, Malignant - pathology
Pleural fluid
small cell carcinoma
Small Cell Lung Carcinoma - diagnosis
Small Cell Lung Carcinoma - drug therapy
Small Cell Lung Carcinoma - pathology
Squamous cell carcinoma
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Description
Summary:There have been few reports on the accuracy of the diagnosis of small-cell carcinoma based on a cytological examination of malignant pleural effusion, so whether or not such a diagnosis is possible using this approach alone remains unclear. We herein report a 76-year-old Japanese man in whom small-cell carcinoma was diagnosed cytopathologically from pleural effusion and squamous cell carcinoma was diagnosed histopathologically from a transbronchial biopsy. Tumor shrinkage was achieved by treatment with docetaxel, but the efficacy of carboplatin plus etoposide was inadequate. If small-cell carcinoma is detected on the basis of pleural fluid cytopathology alone, it is extremely important to perform a histopathological examination to rule out the possibility of other malignancies.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1200-18