Utility and Limitation of Preoperative Neutrophil Lymphocyte Ratio as a Prognostic Factor in Hepatocellular Carcinoma

[ABSTRACT] [Background] The neutrophil lymphocyte ratio (NLR) has been proposed to be a surrogate marker of inflammation and immunological status and to have prognostic value in various malignancies. This study was conducted to clarify the prognostic significance of preoperative NLR in hepatocellula...

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Published in:YONAGO ACTA MEDICA 2018, Vol.61 (4), p.197-203
Main Authors: Uchinaka, Ei, Amisaki, Masataka, Morimoto, Masaki, Tokuyasu, Naruo, Sakamoto, Teruhisa, Honjo, Soichiro, Saito, Hiroaki, Fujiwara, Yoshiyuki
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container_title YONAGO ACTA MEDICA
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creator Uchinaka, Ei
Amisaki, Masataka
Morimoto, Masaki
Tokuyasu, Naruo
Sakamoto, Teruhisa
Honjo, Soichiro
Saito, Hiroaki
Fujiwara, Yoshiyuki
description [ABSTRACT] [Background] The neutrophil lymphocyte ratio (NLR) has been proposed to be a surrogate marker of inflammation and immunological status and to have prognostic value in various malignancies. This study was conducted to clarify the prognostic significance of preoperative NLR in hepatocellular carcinoma (HCC). [Methods] We enrolled 135 patients with histologicallyproven HCC who underwent initial curative hepatectomy. Based on the median NLR values, patients were divided into: NLR>-2.0 (NLR-high, n=69) and NLR
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This study was conducted to clarify the prognostic significance of preoperative NLR in hepatocellular carcinoma (HCC). [Methods] We enrolled 135 patients with histologicallyproven HCC who underwent initial curative hepatectomy. Based on the median NLR values, patients were divided into: NLR&gt;-2.0 (NLR-high, n=69) and NLR&lt;2.0 (NLR-low, n=66). [Results] In univariate analysis, the 5-year overall survival (OS) rates were 59.8%+-6.7% and 75.6%+-6.5% (P=0.028) in the NLR-high and NLR-low groups, respectively. Furthermore, the 5-year disease specific survival rates were 68.6%+-6.7%, and 81.2+-6.4% (P=0.048) in the NLR-high and NLR-low groups, respectively. [Conclusion] Our results showed that high NLR was an independent predictor for OS in hepatectomy-treated HCC, suggesting that NLR may be a novel prognostic biomarker for HCC. 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title Utility and Limitation of Preoperative Neutrophil Lymphocyte Ratio as a Prognostic Factor in Hepatocellular Carcinoma
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