Differential Expression of IL-36 Family Members and IL-38 by Immune and Nonimmune Cells in Patients with Active Inflammatory Bowel Disease

IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bow...

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Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Yamamoto-Furusho, Jesús K., Iturriaga-Goyon, Emilio, Furuzawa-Carballeda, Janette, Fonseca-Camarillo, G.
Format: Article
Language:English
Subjects:
Active control
Arthritis
Atopic dermatitis
Autoimmune diseases
B cells
Biopsy
CD8 antigen
Colon
Colonoscopy
Comparative analysis
Comparative studies
Crohn's disease
Cytokines
Dendritic cells
Dermatitis
Digestive system
Disease control
Endoscopy
Epithelial cells
Gastrointestinal tract
Gene expression
Genes
Immunohistochemistry
Immunology
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory diseases
Interleukin 1
Intestine
Lymphocytes
Lymphocytes T
Macrophages
Medical research
Medicine, Experimental
Mucosa
Patients
Polymerase chain reaction
Proteins
Psoriasis
Rheumatoid arthritis
Rheumatoid factor
RNA
T cells
Therapeutic applications
Tissues
Ulcerative colitis
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Summary:IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), the IL-36α, IL-36β, IL-36γ, IL-36Ra, and IL-38 gene and cell expression and its correlation with clinical activity. Patients and Methods. A cross-sectional and comparative study was performed. Seventy patients with IBD and 30 noninflamed non-IBD controls were enrolled. Gene expression was measured by RT-PCR. Protein expression was detected by double-staining immunohistochemistry. Results. The mRNA expression of IL-36 family members but not IL-38 was increased in colonic mucosa from patients with active ulcerative colitis versus Crohn’s disease group and noninflammatory control group (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/5140691