Assessment of Seven Clinical Tumor Markers in Diagnosis of Non-Small-Cell Lung Cancer

Background. The correlation between tumor markers (TM) and TNM stage of non-small-cell lung cancer (NSCLC) has not been widely reported. Methods. TM levels (CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag) in 424 cases of lung adenocarcinoma (LAC), 166 cases of lung squamous cell carcinoma...

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Bibliographic Details
Published in:Disease markers 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Chen, Zhong-qing, Zhu, Bo, Huang, Ling-sha
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adult
Aged
Aged, 80 and over
Antigens
Antigens, Neoplasm - metabolism
Antigens, Tumor-Associated, Carbohydrate - metabolism
Biomarkers
Biomarkers, Tumor - metabolism
CA-125 Antigen - metabolism
Cancer
Cancer therapies
Carcinoembryonic Antigen - metabolism
Carcinoma, Non-Small-Cell Lung - diagnosis
Carcinoma, Non-Small-Cell Lung - metabolism
Correlation analysis
Diagnosis
Female
Histopathology
Humans
Keratin-19 - metabolism
Laboratories
Lung cancer
Lung cancer, Non-small cell
Lung carcinoma
Lung Neoplasms - diagnosis
Lung Neoplasms - metabolism
Male
Markers
Medical prognosis
Medical research
Medical treatment
Membrane Proteins - metabolism
Metastases
Metastasis
Middle Aged
Mucin-1 - metabolism
Neoplasm Staging
Non-small cell lung carcinoma
Pathology
Sensitivity and Specificity
Squamous cell carcinoma
Statistical analysis
Surgery
Tissues
Tumor markers
Tumors
Young Adult
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Summary:Background. The correlation between tumor markers (TM) and TNM stage of non-small-cell lung cancer (NSCLC) has not been widely reported. Methods. TM levels (CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag) in 424 cases of lung adenocarcinoma (LAC), 166 cases of lung squamous cell carcinoma (LSCC), and 103 cases of benign chest disease (BCD) were analyzed before treatment. Results. By Kendall’s tau-b correlation analysis, CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag were correlated with T stage of LAC (r=0.235, p
ISSN:0278-0240
1875-8630
DOI:10.1155/2018/9845123