Utility of current thrombophilia screening in young patients with stroke and TIA

IntroductionApproximately 40% of strokes in young adults are cryptogenic. The diagnostic yield of thrombophilia screening remains controversial. We aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack (TIA).MethodsWe present a retr...

Full description

Saved in:
Bibliographic Details
Published in:Stroke and vascular neurology 2018-12, Vol.3 (4), p.231-236
Main Authors: Alakbarzade, Vafa, Taylor, Alice, Scully, Marie, Simister, Robert, Chandratheva, Arvind
Format: Article
Language:English
Subjects:
Adult
Age Factors
Antibodies
Antibodies, Antiphospholipid - blood
Binding sites
Biomarkers - blood
Blood Coagulation Factors - genetics
Cardiac arrhythmia
Cardiovascular disease
Carotid arteries
Diagnostic Screening Programs
Female
Genetic Predisposition to Disease
Hemostasis - genetics
Humans
Ischemic Attack, Transient - diagnosis
Ischemic Attack, Transient - etiology
Laboratories
London
Lupus
Male
Middle Aged
Mutation
Original
Predictive Value of Tests
Proteins
Retrospective Studies
Risk Assessment
Risk Factors
Stroke
Stroke - diagnosis
Stroke - etiology
Thrombophilia - blood
Thrombophilia - complications
Thrombophilia - diagnosis
Thrombophilia - genetics
Thrombosis
Transient ischemic attack
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IntroductionApproximately 40% of strokes in young adults are cryptogenic. The diagnostic yield of thrombophilia screening remains controversial. We aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack (TIA).MethodsWe present a retrospective review of all patients with stroke and TIA ≤60 years presenting to University College London Hospital stroke unit and daily TIA clinic from 1 January 2015 to 1 August 2016. Consecutive clinical records and thrombophilia tests, including factor V Leiden (FVL), prothrombin G20210A mutation (PGM), antiphospholipid antibody (APA), and protein S, C and antithrombin (AT) levels, were reviewed.ResultsThe mean age of 628 patients with stroke and TIA was 49.1 years (SD 9.2). Thrombophilia testing was performed in 360 (57%) patients, including 171 with stroke and 189 with TIA. Positive tests were found in 50 (14%) patients, of whom 24 patients were
ISSN:2059-8688
2059-8696
DOI:10.1136/svn-2018-000169