Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine

Highlights • Hemozoin enhanced influenza virus-specific antibody responses in mice. • Mice were immunized with hemozoin-adjuvanted inactivated influenza virus. • Immunized mice were protected against lethal influenza virus challenge. • Hemozoin is a promising adjuvant for inactivated whole virion in...

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Bibliographic Details
Published in:Vaccine 2014-09, Vol.32 (41), p.5295-5300
Main Authors: Uraki, Ryuta, Das, Subash C, Hatta, Masato, Kiso, Maki, Iwatsuki-Horimoto, Kiyoko, Ozawa, Makoto, Coban, Cevayir, Ishii, Ken J, Kawaoka, Yoshihiro
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Allergy and Immunology
Animals
Antibodies, Viral - blood
Antibody Formation
Applied microbiology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Hemagglutination Inhibition Tests
Hemeproteins - pharmacology
Immunization
Immunogenicity
Influenza
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H5N1 Subtype
Influenza Vaccines - immunology
Mice, Inbred BALB C
Microbiology
Miscellaneous
Orthomyxoviridae Infections - prevention & control
Pandemics
Studies
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - immunology
Virology
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Summary:Highlights • Hemozoin enhanced influenza virus-specific antibody responses in mice. • Mice were immunized with hemozoin-adjuvanted inactivated influenza virus. • Immunized mice were protected against lethal influenza virus challenge. • Hemozoin is a promising adjuvant for inactivated whole virion influenza vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.07.079