Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma

Osteosarcoma is the most frequent malignant bone tumor in children and adolescents. Norcantharidin (NCTD) is a purified component from blister beetles and has been identified to exert antitumor effects in a variety of cancer types. However, the antitumor effect of NCTD in osteosarcoma remains to be...

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Bibliographic Details
Published in:Oncology letters 2019-01, Vol.17 (1), p.456-461
Main Authors: Zhu, Yingchun, Mi, Yunfeng, Wang, Zheyang, Jia, Xuewen, Jin, Zhanping
Format: Article
Language:English
Subjects:
Antineoplastic agents
Apoptosis
Biotechnology
Bone cancer
Care and treatment
Cell cycle
Cell growth
Fibroblasts
Genetic aspects
Membranes
Morphology
Oncology
Osteosarcoma
Proteins
Sarcoma
Software
Studies
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Summary:Osteosarcoma is the most frequent malignant bone tumor in children and adolescents. Norcantharidin (NCTD) is a purified component from blister beetles and has been identified to exert antitumor effects in a variety of cancer types. However, the antitumor effect of NCTD in osteosarcoma remains to be elucidated. In the current study, it was first demonstrated that NCTD inhibited proliferation and induced G2/M-phase arrest and cell apoptosis in human osteosarcoma cells. Furthermore, NCTD significantly decreased the phosphorylation of Akt and the mammalian target of rapamycin in human osteosarcoma cells. These results suggest that NCTD is a promising candidate for the treatment of osteosarcoma patients in the future.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9615