Association of BRAF gene and TSHR with cervical lymph node metastasis of papillary thyroid microcarcinoma

Differences in BRAF gene mutation frequency and thyroid-stimulating hormone receptor (TSHR) protein expression in thyroid tissues were detected to investigate their association with local tissue invasion and cervical lymph node metastasis potential of papillary thyroid microcarcinoma (PTMC). The BRA...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2019-01, Vol.17 (1), p.183-194
Main Authors: Zhou, Changxin, Li, Jinbo, Wang, Yu, Xue, Shoukun, Zhang, Yang
Format: Article
Language:English
Subjects:
Age
Care and treatment
Family medical history
Gene expression
Gene mutation
Genetic aspects
Lymphatic system
Medical diagnosis
Metastasis
Mutation
Thoracic surgery
Thyroid cancer
Thyrotropin
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Differences in BRAF gene mutation frequency and thyroid-stimulating hormone receptor (TSHR) protein expression in thyroid tissues were detected to investigate their association with local tissue invasion and cervical lymph node metastasis potential of papillary thyroid microcarcinoma (PTMC). The BRAF gene mutation frequency and TSHR expression in PTMC patients were detected via qPCR and immunohistochemical method, and the association between them was discussed combined with the clinical and pathological parameters. Kruskal-Wallis test was used for the univariate correlation analyses and comparison of mutation rate and expression rate, and Chi-square test was used for the association of central lymph node metastasis with BRAF gene and TSHR. The BRAF mutation only existed in patients with thyroid cancer. Τhe larger the number of metastatic central lymph nodes was, the higher the proportion of BRAF mutation would be. Τhe BRAF mutation was related to the primary lesion size, capsular infiltration and lymph node metastasis of PTMC (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.9572