Regulation of Structure-Specific Endonucleases in Replication Stress

Replication stress results in various forms of aberrant replication intermediates that need to be resolved for faithful chromosome segregation. Structure-specific endonucleases (SSEs) recognize DNA secondary structures rather than primary sequences and play key roles during DNA repair and replicatio...

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Bibliographic Details
Published in:Genes 2018-12, Vol.9 (12), p.634
Main Authors: Kim, Seong Min, Forsburg, Susan L
Format: Article
Language:English
Subjects:
Cell cycle
Cell division
Chromosomes
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA damage
DNA repair
Genomes
Intermediates
Kinases
Nucleotide sequence
Phosphorylation
Proteins
Replication
Resolvase
Review
Ribosomal DNA
Xeroderma pigmentosum
Yeast
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Summary:Replication stress results in various forms of aberrant replication intermediates that need to be resolved for faithful chromosome segregation. Structure-specific endonucleases (SSEs) recognize DNA secondary structures rather than primary sequences and play key roles during DNA repair and replication stress. Holliday junction resolvase MUS81 (methyl methane sulfonate (MMS), and UV-sensitive protein 81) and XPF (xeroderma pigmentosum group F-complementing protein) are a subset of SSEs that resolve aberrant replication structures. To ensure genome stability and prevent unnecessary DNA breakage, these SSEs are tightly regulated by the cell cycle and replication checkpoints. We discuss the regulatory network that control activities of MUS81 and XPF and briefly mention other SSEs involved in the resolution of replication intermediates.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes9120634