A Novel Integrative Processing Technology for the Preparation of Rehmanniae Radix Slices

The traditional processing method for the slices preparation of Rehmanniae roots is time- and energy-consuming and is prone to result in loss of active components during twice water-treatment (once for wash and the other for softening) and drying steps. In this study, we firstly explored an integrat...

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Published in:Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-10
Main Authors: Zhang, Li, Ding, Anwei, Shan, Ming-qiu, Yu, Sheng, Cao, Yu-dan, Chen, Pei-dong, Cheng, Fang-fang, Qian, Yan, Bao, Bei-hua, Yao, Wei-feng
Format: Article
Language:English
Subjects:
Animals
Blood coagulation
Blood platelets
Chinese medicine
Chromatography
Coagulation
Drying
Ethylenediaminetetraacetic acid
Evidence-based medicine
Factorial experiments
Hemorrhage
Hemostasis
Hemostatics
Herbal medicine
High performance liquid chromatography
Laboratory animals
Liquid chromatography
Pharmaceuticals
Rats
Temperature effects
Variance analysis
Viscosity
Water treatment
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cited_by cdi_FETCH-LOGICAL-c499t-c065efa6fcdb7bd95caf48819fcb3036ef83fce2dba5524b4652f4311f87fec23
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container_issue 2018
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container_title Evidence-based complementary and alternative medicine
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creator Zhang, Li
Ding, Anwei
Shan, Ming-qiu
Yu, Sheng
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Chen, Pei-dong
Cheng, Fang-fang
Qian, Yan
Bao, Bei-hua
Yao, Wei-feng
description The traditional processing method for the slices preparation of Rehmanniae roots is time- and energy-consuming and is prone to result in loss of active components during twice water-treatment (once for wash and the other for softening) and drying steps. In this study, we firstly explored an integrative processing technique for Rehmanniae Radix by 2x3 factorial experiment based on the contents of catalpol and verbascoside as measured by HPLC. The potential differences between the traditional stepwise processing technique and the integrative processing technique for catalpol and verbascoside in the prepared slices were investigated. To further confirm the effectiveness of drugs using the integrative processing technique, some pharmacological variables, such as rectal temperature, hematologic parameters (RBC, HGB, HCT, and blood viscosity), and coagulation parameters (TT, APTT, PT and FIB), were detected in a blood-heat and hemorrhage syndrome rat model. Two-way ANOVA analysis showed that drying for 18 h at 50°C was considered as the best combination of process conditions. The mean catalpol and verbascoside contents in the integrative method-processed samples (4.30% and 0.33%, respectively) were higher than those in the traditional method-processed samples (2.61% and 0.21%, respectively). Significant increases in rectal temperature, and hematologic parameters, TT, APTT, and FIB, were observed in the model group rats, compared to the blank group animals (P
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In this study, we firstly explored an integrative processing technique for Rehmanniae Radix by 2x3 factorial experiment based on the contents of catalpol and verbascoside as measured by HPLC. The potential differences between the traditional stepwise processing technique and the integrative processing technique for catalpol and verbascoside in the prepared slices were investigated. To further confirm the effectiveness of drugs using the integrative processing technique, some pharmacological variables, such as rectal temperature, hematologic parameters (RBC, HGB, HCT, and blood viscosity), and coagulation parameters (TT, APTT, PT and FIB), were detected in a blood-heat and hemorrhage syndrome rat model. Two-way ANOVA analysis showed that drying for 18 h at 50°C was considered as the best combination of process conditions. The mean catalpol and verbascoside contents in the integrative method-processed samples (4.30% and 0.33%, respectively) were higher than those in the traditional method-processed samples (2.61% and 0.21%, respectively). Significant increases in rectal temperature, and hematologic parameters, TT, APTT, and FIB, were observed in the model group rats, compared to the blank group animals (P&lt;0.01). Both in the integrative groups and traditional groups, the extracts caused significant decreases in rectal temperature, RBC, HGB, and HCT with increased concentration compared to the model group animals. All coagulation parameters tested were shortened in model rats received two kind prepared slices. There were no significant therapeutic differences between the integrative and the traditional method-processed slices on the hemostasis and hemorheological parameters in this blood-heat and hemorrhage syndrome rat model, indicating that our integrative method may be a feasible technique for processing Rehmanniae Radix slices.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/4524797</identifier><identifier>PMID: 30671128</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Blood coagulation ; Blood platelets ; Chinese medicine ; Chromatography ; Coagulation ; Drying ; Ethylenediaminetetraacetic acid ; Evidence-based medicine ; Factorial experiments ; Hemorrhage ; Hemostasis ; Hemostatics ; Herbal medicine ; High performance liquid chromatography ; Laboratory animals ; Liquid chromatography ; Pharmaceuticals ; Rats ; Temperature effects ; Variance analysis ; Viscosity ; Water treatment</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-10</ispartof><rights>Copyright © 2018 Bei-hua Bao et al.</rights><rights>COPYRIGHT 2018 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2018 Bei-hua Bao et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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In this study, we firstly explored an integrative processing technique for Rehmanniae Radix by 2x3 factorial experiment based on the contents of catalpol and verbascoside as measured by HPLC. The potential differences between the traditional stepwise processing technique and the integrative processing technique for catalpol and verbascoside in the prepared slices were investigated. To further confirm the effectiveness of drugs using the integrative processing technique, some pharmacological variables, such as rectal temperature, hematologic parameters (RBC, HGB, HCT, and blood viscosity), and coagulation parameters (TT, APTT, PT and FIB), were detected in a blood-heat and hemorrhage syndrome rat model. Two-way ANOVA analysis showed that drying for 18 h at 50°C was considered as the best combination of process conditions. The mean catalpol and verbascoside contents in the integrative method-processed samples (4.30% and 0.33%, respectively) were higher than those in the traditional method-processed samples (2.61% and 0.21%, respectively). Significant increases in rectal temperature, and hematologic parameters, TT, APTT, and FIB, were observed in the model group rats, compared to the blank group animals (P&lt;0.01). Both in the integrative groups and traditional groups, the extracts caused significant decreases in rectal temperature, RBC, HGB, and HCT with increased concentration compared to the model group animals. All coagulation parameters tested were shortened in model rats received two kind prepared slices. 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subjects Animals
Blood coagulation
Blood platelets
Chinese medicine
Chromatography
Coagulation
Drying
Ethylenediaminetetraacetic acid
Evidence-based medicine
Factorial experiments
Hemorrhage
Hemostasis
Hemostatics
Herbal medicine
High performance liquid chromatography
Laboratory animals
Liquid chromatography
Pharmaceuticals
Rats
Temperature effects
Variance analysis
Viscosity
Water treatment
title A Novel Integrative Processing Technology for the Preparation of Rehmanniae Radix Slices
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