Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects

Calcium (Ca ) is a versatile second messenger that regulates a number of cellular processes in virtually every type of cell. The inositol 1,4,5-trisphosphate receptor (ITPR) is the only intracellular Ca release channel in cholangiocytes, and is therefore responsible for Ca -mediated processes in the...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-12, Vol.19 (12), p.3913
Main Authors: Rodrigues, Michele Angela, Gomes, Dawidson Assis, Nathanson, Michael Harris
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bile ducts
Bile Ducts - cytology
Bile Ducts - metabolism
Calcium (intracellular)
Calcium ions
Calcium release channels
Calcium Signaling
Calcium signalling
Cell Proliferation
Cystic fibrosis
Epithelial Cells - cytology
Epithelial Cells - metabolism
Genetic engineering
Humans
Inositol 1,4,5-trisphosphate receptors
Inositol 1,4,5-Trisphosphate Receptors - metabolism
Liver diseases
Physiology
Review
Signal transduction
Stem cells
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Summary:Calcium (Ca ) is a versatile second messenger that regulates a number of cellular processes in virtually every type of cell. The inositol 1,4,5-trisphosphate receptor (ITPR) is the only intracellular Ca release channel in cholangiocytes, and is therefore responsible for Ca -mediated processes in these cells. This review will discuss the machinery responsible for Ca signals in these cells, as well as experimental models used to investigate cholangiocyte Ca signaling. We will also discuss the role of Ca in the normal and abnormal regulation of secretion and apoptosis in cholangiocytes, two of the best characterized processes mediated by Ca in this cell type.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19123913