Genomics: New Light on Alzheimer's Disease Research

Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents a major cause of death in many countries. AD is characterized by profound memory loss, disruptions in thinking and reasoning, and changes in personality and behavior followed by malfunctions in various bodily sy...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-11, Vol.19 (12), p.3771
Main Authors: Jung, Yeong Ju, Kim, Yoon Ha, Bhalla, Mridula, Lee, Sung Bae, Seo, Jinsoo
Format: Article
Language:English
Subjects:
Alzheimer's disease
Bioinformatics
Epigenetics
Genome-wide association studies
Kinases
Malfunctions
Next-generation sequencing
Parkinson's disease
Pathology
Review
Risk analysis
Risk factors
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Summary:Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents a major cause of death in many countries. AD is characterized by profound memory loss, disruptions in thinking and reasoning, and changes in personality and behavior followed by malfunctions in various bodily systems. Although AD was first identified over 100 years ago, and tremendous efforts have been made to cure the disease, the precise mechanisms underlying the onset of AD remain unclear. The recent development of next-generation sequencing tools and bioinformatics has enabled us to investigate the role of genetics in the pathogenesis of AD. In this review, we discuss novel discoveries in this area, including the results of genome-wide association studies (GWAS) that have implicated a number of novel genes as risk factors, as well as the identification of epigenetic regulators strongly associated with the onset and progression of AD. We also review how genetic risk factors may interact with age-associated, progressive decreases in cognitive function in patients with AD.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19123771