Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study

Abstract To investigate the association of alcohol intake with colorectal cancer risk according to race/ethnicity as well as sex, lifestyle-related factors, alcoholic beverage type, and anatomical subsite, we analyzed data from 190,698 black, Native Hawaiian, Japanese-American, Latino, and white per...

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Bibliographic Details
Published in:American journal of epidemiology 2019-01, Vol.188 (1), p.67-76
Main Authors: Park, Song-Yi, Wilkens, Lynne R, Setiawan, Veronica Wendy, Monroe, Kristine R, Haiman, Christopher A, Le Marchand, Loïc
Format: Article
Language:English
Subjects:
Age Distribution
Alcohol Drinking - ethnology
Alcoholic beverages
Alcoholic Beverages - classification
Body mass
Body mass index
Body size
California
Cancer
Cohort analysis
Cohort Studies
Colon
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - ethnology
Colorectal Neoplasms - pathology
Confidence intervals
Diet
Dietary fiber
Dietary intake
Ethnicity
Female
Folic acid
Hawaii - epidemiology
Health Behavior
Health risk assessment
Health risks
Heterogeneity
Humans
Life Style
Male
Men
Minority & ethnic groups
Nonsteroidal anti-inflammatory drugs
Original Contributions
Prospective Studies
Race
Rectum
Regression analysis
Regression models
Risk
Risk Factors
Sex
Sex Distribution
Smoking - epidemiology
Statistical analysis
Tumors
Wine
Wines
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Summary:Abstract To investigate the association of alcohol intake with colorectal cancer risk according to race/ethnicity as well as sex, lifestyle-related factors, alcoholic beverage type, and anatomical subsite, we analyzed data from 190,698 black, Native Hawaiian, Japanese-American, Latino, and white persons in Hawaii and California in the Multiethnic Cohort Study, with 4,923 incident cases during a 16.7-year follow-up period (1993–2013). In multivariate Cox regression models, the hazard ratio was 1.16 (95% confidence interval (CI): 1.01, 1.34) for 15.0–29.9 g/day of alcohol and 1.28 (95% CI: 1.12, 1.45) for ≥30.0 g/day among men, and 1.06 (95% CI: 0.85, 1.32) and 1.15 (95% CI: 0.92, 1.43), respectively, among women, compared with nondrinkers (P for heterogeneity according to sex = 0.74). An increased risk was apparent among Native Hawaiians, Japanese Americans, Latinos, and white persons and among individuals with body mass index
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwy208