Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment

Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also r...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical investigation 2018-11, Vol.48 (S2), p.e12939-n/a
Main Authors: Pantarelli, Chiara, Welch, Heidi C. E.
Format: Article
Language:English
Subjects:
Adhesion
Cell activation
Cell Adhesion - physiology
Cell Movement - physiology
Cytoskeleton
Guanine Nucleotide Exchange Factors - physiology
guanine‐nucleotide exchange factors
Humans
Leukocyte migration
Leukocytes (neutrophilic)
Neutrophil Infiltration - physiology
Neutrophils
Neutrophils - enzymology
Neutrophils - physiology
Neutrophils. Guest Editor: Dirk Roos
Proteins
Proto-Oncogene Proteins c-vav - physiology
P‐Rex1
rac GTP-Binding Proteins - physiology
rac1 GTP-Binding Protein - physiology
Recruitment
Review
Rho Guanine Nucleotide Exchange Factors - physiology
Rho‐GTPases
Signal Transduction - physiology
small G proteins
T-Lymphoma Invasion and Metastasis-inducing Protein 1 - physiology
Vav
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment.
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.12939