Rutin Attenuates Vancomycin-Induced Nephrotoxicity by Ameliorating Oxidative Stress, Apoptosis, and Inflammation in Rats

• Published in: Antimicrobial agents and chemotherapy 2019-01, Vol.63 (1)
• Main Authors: Qu, Shaoqi, Dai, Cunchun, Lang, Fengting, Hu, Longfei, Tang, Qihe, Wang, Haixia, Zhang, Yanping, Hao, Zhihui
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Blood Urea Nitrogen; Creatinine - blood; Heme Oxygenase (Decyclizing) - metabolism; Hexosaminidases - urine; Inflammation; Inflammation - drug therapy; Kidney - drug effects; Kidney Diseases; Kidney Diseases - chemically induced; Kidney Diseases - drug therapy; Kidney Diseases - prevention & control; Male; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; Oxidative Stress; Oxidative Stress - drug effects; Pharmacology; Rats; Rats, Wistar; Renal Insufficiency - chemically induced; Renal Insufficiency - drug therapy; Rutin; Rutin - pharmacology; Vancomycin - toxicity
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01545-18

Nephrotoxicity is the major limiting factor for the clinical use of vancomycin (VCM) for treatment of serious infections caused by multiresistant Gram-positive bacteria. This study investigated the renal protective activity of rutin in a rat model of VCM-induced kidney injury in male Wistar rats. VCM administered intraperitoneally at 200 mg/kg twice daily for 7 successive days resulted in significant elevation of blood urea nitrogen and creatinine, as well as urinary -acetyl-β-D-glucosaminidase. Coadministration of VCM with oral rutin at 150 mg/kg significantly reduced these markers of kidney damage. Rutin also significantly attenuated VCM-induced oxidative stress, inflammatory cell infiltration, apoptosis, and decreased interleukin-1β and tumor necrosis factor alpha levels (all