Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata

Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in mutational frequency of resistance or propensity to develop mutations. The objective of this study was to measure spontaneous and mutation rates among strains. Twenty bloods...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2019-01, Vol.63 (1)
Main Authors: Shields, Ryan K, Kline, Ellen G, Healey, Kelley R, Kordalewska, Milena, Perlin, David S, Nguyen, M Hong, Clancy, Cornelius J
Format: Article
Language:English
Subjects:
Anidulafungin
Anidulafungin - pharmacology
Antifungal Agents
Antifungal Agents - pharmacology
Candida glabrata
Candida glabrata - drug effects
Candida glabrata - enzymology
Candida glabrata - genetics
Candida glabrata - isolation & purification
Candidiasis - microbiology
Candidiasis, Invasive - microbiology
Caspofungin
Caspofungin - pharmacology
Drug Resistance, Fungal
Drug Resistance, Fungal - drug effects
Drug Resistance, Fungal - genetics
Fungal Proteins - genetics
Fungal Proteins - metabolism
Gene Expression
Genetic Loci
Glucosyltransferases
Glucosyltransferases - genetics
Glucosyltransferases - metabolism
Humans
Mechanisms of Resistance
Micafungin
Micafungin - pharmacology
Microbial Sensitivity Tests
Mutation Rate
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Summary:Echinocandins are front-line agents for treatment of invasive candidiasis. There are no reported agent-specific differences in mutational frequency of resistance or propensity to develop mutations. The objective of this study was to measure spontaneous and mutation rates among strains. Twenty bloodstream isolates from patients with or without prior echinocandin exposure were included. Minimum inhibitory concentrations (MICs), minimum fungicidal concentrations (MFCs), and mutation prevention concentrations were higher for caspofungin than for anidulafungin (  
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01692-18