Protein synthesis and quality control in aging

Aging is characterized by the accumulation of damage and other deleterious changes, leading to the loss of functionality and fitness. Age-related changes occur at most levels of organization of a living organism (molecular, organellar, cellular, tissue and organ). However, protein synthesis is a maj...

Full description

Saved in:
Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2018-12, Vol.10 (12), p.4269-4288
Main Authors: Anisimova, Aleksandra S, Alexandrov, Alexander I, Makarova, Nadezhda E, Gladyshev, Vadim N, Dmitriev, Sergey E
Format: Article
Language:English
Subjects:
Aging - physiology
Gene Expression Regulation - physiology
Humans
Protein Biosynthesis - physiology
Proteome - metabolism
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aging is characterized by the accumulation of damage and other deleterious changes, leading to the loss of functionality and fitness. Age-related changes occur at most levels of organization of a living organism (molecular, organellar, cellular, tissue and organ). However, protein synthesis is a major biological process, and thus understanding how it changes with age is of paramount importance. Here, we discuss the relationships between lifespan, aging, protein synthesis and translational control, and expand this analysis to the various aspects of proteome behavior in organisms with age. Characterizing the consequences of changes in protein synthesis and translation fidelity, and determining whether altered translation is pathological or adaptive is necessary for understanding the aging process, as well as for developing approaches to target dysfunction in translation as a strategy for extending lifespan.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.101721