Potential application of cell reprogramming techniques for cancer research

The ability to control the transition from an undifferentiated stem cell to a specific cell fate is one of the key techniques that are required for the application of interventional technologies to regenerative medicine and the treatment of tumors and metastases and of neurodegenerative diseases. Re...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2019-01, Vol.76 (1), p.45-65
Main Authors: Saito, Shigeo, Lin, Ying-Chu, Nakamura, Yukio, Eckner, Richard, Wuputra, Kenly, Kuo, Kung-Kai, Lin, Chang-Shen, Yokoyama, Kazunari K.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer research
Cell Biology
Cell fate
Cellular Reprogramming
Cellular Reprogramming Techniques - methods
Epigenesis, Genetic
Epigenetics
Gene Expression Regulation, Neoplastic
Humans
Life Sciences
Medical research
Metastases
Microenvironments
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - cytology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Neurodegenerative diseases
Neurological diseases
Nuclear transfer
Regenerative medicine
Review
Somatic cell nuclear transfer
Stability
Stem cells
Tumor Microenvironment
Tumor suppressor genes
Tumors
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Summary:The ability to control the transition from an undifferentiated stem cell to a specific cell fate is one of the key techniques that are required for the application of interventional technologies to regenerative medicine and the treatment of tumors and metastases and of neurodegenerative diseases. Reprogramming technologies, which include somatic cell nuclear transfer, induced pluripotent stem cells, and the direct reprogramming of specific cell lineages, have the potential to alter cell plasticity in translational medicine for cancer treatment. The characterization of cancer stem cells (CSCs), the identification of oncogene and tumor suppressor genes for CSCs, and the epigenetic study of CSCs and their microenvironments are important topics. This review summarizes the application of cell reprogramming technologies to cancer modeling and treatment and discusses possible obstacles, such as genetic and epigenetic alterations in cancer cells, as well as the strategies that can be used to overcome these obstacles to cancer research.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-018-2924-7