Comparative mRNA and miRNA expression in European mouflon (Ovis musimon) and sheep (Ovis aries) provides novel insights into the genetic mechanisms for female reproductive success

Prolific breeds of domestic sheep (Ovis aries) are important genetic resources due to their reproductive performance, which is characterized by multiple lambs per birth and out-of-season breeding. However, the lack of a comprehensive understanding of the genetic mechanisms underlying the important r...

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Bibliographic Details
Published in:Heredity 2019-02, Vol.122 (2), p.172-186
Main Authors: Yang, Ji, Li, Xin, Cao, Yin-Hong, Pokharel, Kisun, Hu, Xiao-Ju, Chen, Ze-Hui, Xu, Song-Song, Peippo, Jaana, Honkatukia, Mervi, Kantanen, Juha, Li, Meng-Hua
Format: Article
Language:English
Subjects:
Animal husbandry
Animal reproduction
Animals
Biological evolution
Breeding
Breeding success
Domestic animals
Endometrium
Female
Females
Fertilization
Gene expression
Gene Expression Profiling
Gene sequencing
Genes
Genetic resources
Genomics
Male
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Oogenesis
Ovis
Ovis aries
Ovis musimon
Regulation
Reproduction
Ribonucleic acid
RNA
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sheep
Sheep - classification
Sheep - genetics
Sheep - physiology
Sheep, Domestic - classification
Sheep, Domestic - genetics
Sheep, Domestic - physiology
Species
Transcriptome
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Summary:Prolific breeds of domestic sheep (Ovis aries) are important genetic resources due to their reproductive performance, which is characterized by multiple lambs per birth and out-of-season breeding. However, the lack of a comprehensive understanding of the genetic mechanisms underlying the important reproductive traits, particularly from the evolutionary genomics perspective, has impeded the efficient advancement of sheep breeding. Here, for the first time, by performing RNA-sequencing we built a de novo transcriptome assembly of ovarian and endometrial tissues in European mouflon (Ovis musimon) and performed an mRNA-miRNA integrated expression profiling analysis of the wild species and a highly prolific domestic sheep breed, the Finnsheep. We identified several novel genes with differentially expressed mRNAs (e.g., EREG, INHBA, SPP1, AMH, TDRD5, and ZP2) between the wild and domestic sheep, which are functionally involved in oocyte and follicle development and fertilization, and are significantly (adjusted P-value 
ISSN:0018-067X
1365-2540
DOI:10.1038/s41437-018-0090-1