Androgen receptor and soy isoflavones in prostate cancer

Androgens and androgen receptor (AR) play a critical role not only in normal prostate development, but also in prostate cancer. For that reason, androgen deprivation therapy (ADT) is the primary treatment for prostate cancer. However, the majority of patients develop castration-resistant prostate ca...

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Bibliographic Details
Published in:Molecular and clinical oncology 2019-02, Vol.10 (2), p.191-204
Main Authors: Sivoňov, Monika, Kapl n, Peter, Tatarkov, Zuzana, Lichardusov, Lucia, Dušenka, R bert, Jurečekov, Jana
Format: Article
Language:English
Subjects:
Amino acids
Androgen receptors
Androgens
Antigens
Breast cancer
Cancer prevention
Cancer therapies
Cancer treatment
Care and treatment
Cell cycle
Development and progression
Genetic aspects
Health
Health aspects
Heat shock proteins
Hormones
Isoflavones
Kinases
Ligands
Mortality
Oncology
Prostate cancer
Retirement benefits
Review
Sex hormones
Soy products
Steroid hormones
Studies
Testosterone
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Summary:Androgens and androgen receptor (AR) play a critical role not only in normal prostate development, but also in prostate cancer. For that reason, androgen deprivation therapy (ADT) is the primary treatment for prostate cancer. However, the majority of patients develop castration-resistant prostate cancer, which eventually leads to mortality. Novel therapeutic approaches, including dietary changes, have been explored. Soy isoflavones have become a focus of interest because of their positive health benefits on numerous diseases, particularly hormone-related cancers, including prostate and breast cancers. An important strategy for the prevention and/or treatment of prostate cancer might thus be the action of soy isoflavones on the AR signaling pathway. The current review article provides a detailed overview of the anticancer potential of soy isoflavones (genistein, daidzein and glycitein), as mediated by their effect on AR.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2018.1792