In vivo confocal laser scanning microscopy imaging of skin inflammation: Clinical applications and research directions

confocal laser scanning microscopy (CLSM) is a novel imaging technique that provides noninvasive, morphological characterization of skin structures with a resolution that is very close to that of light microscopy. Moreover, as it allows repeated imaging of the same skin area at different time-points...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2019-02, Vol.17 (2), p.1004-1011
Main Authors: Ilie, Mihaela Adriana, Caruntu, Constantin, Lixandru, Daniela, Tampa, Mircea, Georgescu, Simona-Roxana, Constantin, Maria-Magdalena, Constantin, Carolina, Neagu, Monica, Zurac, Sabina Andrada, Boda, Daniel
Format: Article
Language:English
Subjects:
Biopsy
Blood
Care and treatment
Dermatitis
Diagnosis
Disease
Fluorescence microscopy
Inflammation
Keratin
Lasers
Methods
Microscopy
Morphology
Patient outcomes
Psoriasis
Review
Skin
Skin diseases
Studies
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Summary:confocal laser scanning microscopy (CLSM) is a novel imaging technique that provides noninvasive, morphological characterization of skin structures with a resolution that is very close to that of light microscopy. Moreover, as it allows repeated imaging of the same skin area at different time-points, it is an excellent method for monitoring disease course, response to treatment or specific stimuli and a path to study dynamic phenomena in real-time. To date, two different variants of CLSM have been authorized in dermatological field, namely the reflectance confocal microscopy predominantly for clinical diagnosis and the fluorescence confocal microscopy mainly for research purposes. This study describes the principles of CLSM technique, its role in the diagnosis and monitoring of inflammatory skin diseases, as well as some promising research directions to study the dynamics of skin inflammation using this method. CLSM evaluation of inflammatory dermatoses and of the skin inflammatory component in various diseases has an undoubted potential with broad applications ranging from clinical, morphological to experimental, functional studies involving the skin.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.6981