Progesterone hypersensitivity: Case report with favorable evolution

Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all u...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2019-02, Vol.17 (2), p.1125-1127
Main Authors: Senila, Simona C, Ungureanu, Loredana, Candrea, Elisabeta, Danescu, Sorina, Vasilovici, Alina, Cosgarea, Rodica, Dionisie, Vlad
Format: Article
Language:English
Subjects:
Allergy
Angioneurotic edema
Apoptosis
Asthma
Birth control
Care and treatment
Case reports
Case studies
Clinical outcomes
Dermatitis
Development and progression
Disease control
Hives (Disease)
In vitro fertilization
Medical schools
Menstruation
Menstruation disorders
Patients
Pregnancy
Progestational hormones
Progesterone
Sex hormones
Skin
Urticaria
Womens health
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Summary:Progesterone hypersensitivity or autoimmune progesterone dermatitis is characterized by heterogeneous skin eruptions that cyclically aggravate during the second half of the menstrual cycle, corresponding to a rise in the progesterone level. Clinical presentation is highly variable and includes all urticaria manifestations with or without angioedema, vesiculobullous, eczematous, purpuric or target-like lesions on the skin and mucous membrane. Both endogenous progesterone as well as exogenous progestogens may represent an initial trigger. We report a case of progesterone hypersensitivity in a 27-year old woman with favorable evolution only on topical therapy, the positive clinical outcome being maintained during a subsequent pregnancy and postpartum period.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.7055