Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children

Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child’s risk of ASD, developmental delay/disorder (DD)...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2019-01, Vol.49 (1), p.376-382
Main Authors: Rubenstein, Eric, Young, Jessica C., Croen, Lisa A., DiGuiseppi, Carolyn, Dowling, Nicole F., Lee, Li-Ching, Schieve, Laura, Wiggins, Lisa D., Daniels, Julie
Format: Article
Language:English
Subjects:
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Autism
Autism Spectrum Disorder - epidemiology
Autistic children
Behavioral Science and Psychology
Brain
Brief Report
Case Studies
Child
Child and School Psychology
Child Development
Child, Preschool
Children
Complications and side effects
Confidence intervals
Correlation
Developmentally delayed children
Drug Therapy
Drug Utilization - statistics & numerical data
Female
Health aspects
Humans
Male
Mothers
Narcotics
Neurodevelopment
Neurosciences
Opioids
Pediatrics
Pervasive Developmental Disorders
Pregnancy
Prenatal drug exposure
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Influences
Prescription drugs
Prescriptions
Psychology
Public Health
Risk
Risk factors
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Description
Summary:Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child’s risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-018-3721-8