Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma

Purpose Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. The aim of this study...

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Bibliographic Details
Published in:International journal of colorectal disease 2019-02, Vol.34 (2), p.309-317
Main Authors: Schellerer, Vera S., Langheinrich, Melanie C., Zver, Veronika, Grützmann, Robert, Stürzl, Michael, Gefeller, Olaf, Naschberger, Elisabeth, Merkel, Susanne
Format: Article
Language:English
Subjects:
Analysis
Cancer
Carcinoembryonic antigen
Carcinoma
CEA (Oncology)
Cell adhesion
Colorectal cancer
Colorectal carcinoma
Data processing
Development and progression
Diagnosis
Enzyme immunoassay
Enzyme-linked immunosorbent assay
Enzymes
Gastroenterology
Hepatology
Intercellular adhesion molecule 1
Internal Medicine
Medicine
Medicine & Public Health
Multivariate analysis
Original
Original Article
Proctology
Prognosis
Risk factors
Risk groups
Surgery
Survival
Tumor markers
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Summary:Purpose Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. The aim of this study was to evaluate the prognostic relevance of sICAM-1 combined with CEA in patients with CRC. Methods In blood samples of 297 CRC patients, sICAM-1 was determined by ELISA and CEA by microparticle enzyme immunoassay the day before oncologic resection. Separation in patients with sICAM-1 high and sICAM-1 low was performed by minimum p value approach; separation in CEA normal and elevated was performed according to the established diagnostic cutoff. Clinical data were obtained from the prospective collected data from the Erlangen Registry for Colorectal Carcinomas. Results Cancer-related 5-year survival rate of patients with sICAM-1 low (
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-018-3198-0