Anorectal Cancer with Bone Marrow and Leptomeningeal Metastases

This is an interesting case of anorectal signet ring carcinoma with first presentation of an early stage disease, showing the aggressive disease and the undetectable behavior of this type of histology which can mislead diagnosis. Brain/CNS metastasis from colorectal cancer (CRC) is rare occurring in...

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Published in:Case reports in oncological medicine 2018-01, Vol.2018 (2018), p.1-6
Main Authors: Mohamed, Wael, Alzibair, Zuhair, Ismail, Amal Mostafa, Saleh, Yasser M., Al-Dhaibani, Nasser, Zeeneldin, Ahmed A., Moona, Mohamed Shafi
Format: Article
Language:English
Subjects:
Acids
Antigens
Blood
Blood platelets
Bone marrow
Cancer therapies
Case Report
Case reports
Chemotherapy
Colorectal cancer
Dysphagia
Family medical history
Hemoglobin
Males
Metastasis
Neutrophils
Oncology
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container_issue 2018
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container_title Case reports in oncological medicine
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creator Mohamed, Wael
Alzibair, Zuhair
Ismail, Amal Mostafa
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description This is an interesting case of anorectal signet ring carcinoma with first presentation of an early stage disease, showing the aggressive disease and the undetectable behavior of this type of histology which can mislead diagnosis. Brain/CNS metastasis from colorectal cancer (CRC) is rare occurring in 3% of cases, and leptomeningeal carcinomatosis (LMC) is extremely rare in CRC (
doi_str_mv 10.1155/2018/9246139
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Brain/CNS metastasis from colorectal cancer (CRC) is rare occurring in 3% of cases, and leptomeningeal carcinomatosis (LMC) is extremely rare in CRC (&lt;0.02%). Symptoms and signs of LMC are pleomorphic and may be localized to three compartments: cerebral hemispheres, cranial nerves, and spinal cords and roots. Treatment of metastatic rectal cancer has been improving over the last few years with a lot of changes toward longer survival and improvement in quality of life and to change the disease into a chronic condition. However, in our case, the overall survival from the onset of LMC was 3 weeks only. Revising the evidence in the treatment of signet ring histology of rectal cancer, there is no specific treatment recommendation that is for this histology and for such very aggressive behavior which could be considered as a separate entity to the classic adenocarcinoma histology.</description><identifier>ISSN: 2090-6706</identifier><identifier>EISSN: 2090-6714</identifier><identifier>DOI: 10.1155/2018/9246139</identifier><identifier>PMID: 30693122</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Antigens ; Blood ; Blood platelets ; Bone marrow ; Cancer therapies ; Case Report ; Case reports ; Chemotherapy ; Colorectal cancer ; Dysphagia ; Family medical history ; Hemoglobin ; Males ; Metastasis ; Neutrophils ; Oncology</subject><ispartof>Case reports in oncological medicine, 2018-01, Vol.2018 (2018), p.1-6</ispartof><rights>Copyright © 2018 Ahmed Zeeneldin et al.</rights><rights>Copyright © 2018 Ahmed Zeeneldin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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subjects Acids
Antigens
Blood
Blood platelets
Bone marrow
Cancer therapies
Case Report
Case reports
Chemotherapy
Colorectal cancer
Dysphagia
Family medical history
Hemoglobin
Males
Metastasis
Neutrophils
Oncology
title Anorectal Cancer with Bone Marrow and Leptomeningeal Metastases
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