Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines

A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a...

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Bibliographic Details
Published in:RSC advances 2018-11, Vol.8 (69), p.39731-39734
Main Authors: Miller, Maya, Tshuva, Edit Y
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Chemistry
Crystallography
Enantiomers
Toxicity
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Summary:A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a beneficial activity of both enantiomers rendering enantiomeric resolution unnecessary.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra08925f