Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents

Conventional emulsion‐based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposure. Encapsulation of the UVB filter padimate O within bioadhe...

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Bibliographic Details
Published in:Bioengineering & translational medicine 2019-01, Vol.4 (1), p.129-140
Main Authors: Suh, Hee‐Won, Lewis, Julia, Fong, Linda, Ramseier, Julie Ying, Carlson, Kacie, Peng, Zheng‐Hong, Yin, Emily Sara, Saltzman, W. Mark, Girardi, Michael
Format: Article
Language:English
Subjects:
Biodegradability
Chromatography
clinical study
Dermatitis
drug delivery
FDA approval
Formulations
In vitro methods and tests
Lactic acid
nanoparticle
Nanoparticles
Octocrylene
Photodegradation
Polyglycerols
Polymers
Radiation damage
reactive oxygen species
Research Report
Research Reports
Retention
Skin cancer
Studies
Sun screens
Sunburn & sun tanning
Sunscreen
Ultraviolet filters
Ultraviolet radiation
UV stabilizers
Water purification
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Summary:Conventional emulsion‐based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposure. Encapsulation of the UVB filter padimate O within bioadhesive biodegradable nanoparticles (BNPs) composed of poly(d,l‐lactic acid)‐hyperbranched polyglycerol was previously shown to enhance UVR protection while preventing skin absorption. Herein, we assess the capacity of BNP co‐incorporation of avobenzone and octocrylene to provide broad‐spectrum UVR protection. The ratio of UV filters within nanoparticles (NPs) was optimized for filter–filter stabilization upon UV irradiation and maximum drug loading. In vitro water‐resistance test showed significant particle retention at 85% over 3 hr. In a pilot clinical study, protection against UVR‐induced erythema of BNPs was found to be comparable to the FDA standard P2. Thus, sunscreen formulations utilizing BNP incorporation of a combination of organic filters may offer key safety and performance advantages.
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10092