Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy

Relapse remains a major obstacle to the survival of patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation. A disintegrin-like and metalloprotease with a thrombospondin type 1 motif (ADMATS13), which cleaves von Willebrand factor multimers into less active fr...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-01, Vol.20 (1), p.214
Main Authors: Nomoto, Haruka, Takami, Akiyoshi, Espinoza, J Luis, Onizuka, Makoto, Kashiwase, Koichi, Morishima, Yasuo, Fukuda, Takahiro, Kodera, Yoshihisa, Doki, Noriko, Miyamura, Koichi, Mori, Takehiko, Nakao, Shinji, Morishita, Eriko
Format: Article
Language:English
Subjects:
ABO system
ADAMTS13 Protein - genetics
Adolescent
Adult
Aged
Blood cancer
Bone marrow
Bone Marrow Transplantation
Child
Child, Preschool
Compatibility
Cyclosporins
Cytomegalovirus
Disease-Free Survival
Donors
Female
Gene polymorphism
Genotype & phenotype
Graft-versus-host reaction
Hematologic Neoplasms - genetics
Hematologic Neoplasms - therapy
Histocompatibility antigen HLA
Humans
Infant
Infections
Kaplan-Meier Estimate
Leukemia
Lymphocytes
Male
Malignancy
Middle Aged
Multivariate Analysis
Neutrophils
Nucleotides
Patients
Polymorphism
Polymorphism, Single Nucleotide - genetics
Prophylaxis
Recurrence
Sex
Single-nucleotide polymorphism
Stem cell transplantation
Subgroups
Tacrolimus
Transplant Recipients
Transplantation
Transplants & implants
Treatment Outcome
Young Adult
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Summary:Relapse remains a major obstacle to the survival of patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation. A disintegrin-like and metalloprotease with a thrombospondin type 1 motif (ADMATS13), which cleaves von Willebrand factor multimers into less active fragments, is encoded by the gene and has a functional single-nucleotide polymorphism (SNP) rs2285489 (C > T). We retrospectively examined whether rs2285489 affected the transplant outcomes in a cohort of 281 patients who underwent unrelated human leukocyte antigen (HLA)-matched bone marrow transplantation for hematologic malignancies. The recipient C/C genotype, which putatively has low inducibility, was associated with an increased relapse rate (hazard ratio [HR], 3.12; 95% confidence interval [CI], 1.25⁻7.77; = 0.015), resulting in a lower disease-free survival rate in the patients with a recipient C/C genotype (HR, 1.64; 95% CI, 1.01⁻2.67; = 0.045). Therefore, rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20010214